报告时间: 2017年6月17日上午9:30

报告地点: 纺织学院3004室

报告人及简介: Hongjun Wang，Associate Professor of Biomedical Engineering, Associate Professor of Chemistry, Associate Professor of Chemical Biology, Stevens Institute of Technology, New Jersey, US. His research interests include complex tissue formation, 3D in vitro tissue model, biomimetic materials design, cell-materials interaction, nanomedicine, and regenerative medicine. He obtained the 1st Ph.D. in Polymer Chemistry and Physics (Biomaterials) in 1998 from Nankai University and University of Twente, Enschede, the Netherland, and the 2nd Ph.D. in Biomedical Engineering (Tissue Engineering) in 2003 from Harvard Medical School and Massachusetts General Hospital, Boston. He was working as the research fellow from 2003 to 2005. Out of 70 peer-reviewed journal publications in addition to 5 pending patents, 2 issued patents, 7 provisional patents, 2 editorial papers, 8 book chapters, 1 book, over 100 conference abstracts & proceedings and invited talks since 1994.

报告大纲: After decades of efforts from both academic and industrial researchers, a great mass of knowledge and tremendous progress has been made in tissue engineering, which has great potential in both regenerative medicine and as an in vitro testing platform.However, in creation of large tissues/organs with multiple functionalities and hierarchical structures, several challenges, e.g., vascularization and spatially controlled cell organization confound current tissue engineering strategy.Recognition of these challenges inspires our ongoing efforts in creating vasculature in tissue-engineered substitutes and the development of bottom-up tissue engineering. The former enables the free exchange of nutrient and gas across the large substitutes, and the latter allows straightforward manipulation of the spatial arrangement of multiple cell types and customization of the growth environment for individual cell type. Along with this endeavor, the configuration of a cell-friendly microenvironment is critical to guarantee the desirable cell phenotype, leading to functional tissue formation. In this regard, a biomimetic approach is taken in biomaterial design to maximally recapture the native cell-residing environment on a micro/nanoscale.